ea0050s2.1 | When receptors go rogue | SFEBES2017
Hunter Richard
Glucocorticoids (GC) are involved recruiting the energetic response to stress and act principally via the glucocorticoid receptor (GR). The GR is classically understood to function as a nuclear transcription factor. However, the nuclear genome is not the only genome in eukaryotic cells. The mitochondria also contain a small circular chromosome the mitochondrial DNA (mtDNA) that encodes 13 proteins. It has been established that, in the brain and other systems, the...